The Multiple Pharmaceutical Potential of Curcumin in Parkinson's Disease

Author(s): Hong-Fang Ji , Liang Shen .

Journal Name: CNS & Neurological Disorders - Drug Targets

Volume 13 , Issue 2 , 2014

Become EABM
Become Reviewer

Abstract:

Parkinson's disease (PD) is one of the most common neurodegenerative diseases in the elderly. In recent years increasing evidence supports the pharmaceutical potential of curcumin, a polyphenolic compound in the spice turmeric, against PD. Here we briefly summarize the pharmacological activities of curcumin in vitro and in animal models of PD, including counteracting oxidative stress and inflammation, preventing α-synuclein aggregation and fibrillation, and inhibiting monoamine oxidase B, which endow curcumin with multiple pharmaceutical activities against PD and encourage further studies to investigate its clinical effects.

Keywords: Parkinson's disease, curcumin, antioxidant, anti-inflammation, anti-aggregation.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 13
ISSUE: 2
Year: 2014
Page: [369 - 373]
Pages: 5
DOI: 10.2174/18715273113129990077
Price: $58

Article Metrics

PDF: 38