Investigation of Reactions Between Binucleophilic Reagents with 2-(2-Oxindolin-3-ylidene)malononitrile Derivatives | BenthamScience

Investigation of Reactions Between Binucleophilic Reagents with 2-(2-Oxindolin-3-ylidene)malononitrile Derivatives

Author(s): Mohammad Seifi, Hassan Sheibani.

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 7 , 2013

Abstract:

Nucleophilic addition of hydrazines and thiosemicarbazide to the 2-(2-oxoindolin-3-ylidene) malononitrile derivatives 1, followed by elimination of malononitrile, lead to 3-(2-arylhydrazono)indolin-2-ones and 1-(2-oxoindolin-3- ylidene)thiosemicarbzides respectively. Also the reaction of compounds 1 with 4-substituted thiosemicarbazides, followed by elimination and cyclization, afforded spiro(indolone-3,2´-[1,3,4]thiadiazol)-2-ones. So all of these nucleophilic reactions with isatin and substituted isatins released the same products.

Keywords: Hydrazones, 2-(2-oxindolin-3-ylidene)malononitriles, 4-substituted thiosemicarbazides.

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Article Details

VOLUME: 10
ISSUE: 7
Year: 2013
Page: [478 - 481]
Pages: 4
DOI: 10.2174/1570178611310070004
Price: $58

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