Cell-free DNA: Characteristics, Detection and its Applications in Myocardial Infarction

Author(s): Rongrong Jing, Ming Cui, Huimin Wang, Shaoqing Ju.

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 28 , 2013

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Abstract:

Much attention has been focused on cell-free DNA (cf-DNA) and its levels in the plasma, serum and body fluids of pregnant women and patients with cancer or autoimmune disease, and those with severe trauma; however, knowledge of its biology and relationship with myocardial infarction (MI) is still at an early stage. This paper introduces general aspects of the nomenclature, structure, function, release mechanisms and methodology of cf-DNA and summarizes the current literature on concentration variation and regulatory mechanisms in MI.

Keywords: Cell-free DNA, biological characteristics, methodology, myocardial infarction.

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Article Details

VOLUME: 19
ISSUE: 28
Year: 2013
Page: [5135 - 5145]
Pages: 11
DOI: 10.2174/1381612811319280012
Price: $58

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