We summarize the alterations of classical neurotransmitters and neuropeptides, including their specific
subreceptors, involved in schizophrenia. The essential susceptibility genes in schizophrenia and their coherence to
neurotransmitter alterations are highlighted. In this sense, dopamine and serotonin hyperactivity in the mesolimbic system
and the hippocampus is due to a reduced presynaptic inhibition carried out by GABA and glutamate, which is due to the
susceptibility genes. A neuronal network in the brain regions involved in schizophrenia is developed in order to derive
novel therapeutic approaches. A survey of the mechanisms of action of conventional and newer antipsychotic drug is
given. We suggest the appropriate antipsychotic drugs considering the symptoms of schizophrenic and their possible side
effects. It is important to examine the susceptibility genes in a cohort of patients in order to find out which patients profit
more from antipsychotic drugs: those that exert a stronger D2 antagonistic effect or those that exert a stronger 5HT2A
antagonistic effect. One question to be answered is whether refractory symptoms such as persistent acoustic hallucinations
could be improved with novel antipsychotic drugs.
Keywords: Acetylcholine, cholecystokinin, dopamine, GABA, glutamate, neuronal network, neurotensin, serotonin.
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