The simultaneous separation and quantification of the analytes within the minimum analysis time and the
maximum resolution and efficiency are the main objectives in the development of a capillary electrophoretic method for
the determination of solutes. In this paper we describe a specific, sensitive and robust method, using capillary zone
electrophoresis with internal standard and UV detection, for the separation and quantification of the anti-arrhythmic drug
mexiletine, its main phase I metabolites, and its main nitrogenous degradation product.
Keywords: Anti-arrhythmics, capillary zone electrophoresis, metabolites, mexiletine.
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