Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

Back

Capillary Zone Electrophoresis for Separation and Quantitative Determination of Mexiletine and its Main Phase I Metabolites

Author(s): Claudio Bruno, Maria Maddalena Cavalluzzi, Alessia Carocci, Alessia Catalano, Carlo Franchini, Giovanni Lentini.

Abstract:

The simultaneous separation and quantification of the analytes within the minimum analysis time and the maximum resolution and efficiency are the main objectives in the development of a capillary electrophoretic method for the determination of solutes. In this paper we describe a specific, sensitive and robust method, using capillary zone electrophoresis with internal standard and UV detection, for the separation and quantification of the anti-arrhythmic drug mexiletine, its main phase I metabolites, and its main nitrogenous degradation product.

Keywords: Anti-arrhythmics, capillary zone electrophoresis, metabolites, mexiletine.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

VOLUME: 7
ISSUE: 1
Year: 2013
Page: [52 - 57]
Pages: 6
DOI: 10.2174/18723128112069990011