Capillary Zone Electrophoresis for Separation and Quantitative Determination of Mexiletine and its Main Phase I Metabolites
Maria Maddalena Cavalluzzi,
The simultaneous separation and quantification of the analytes within the minimum analysis time and the
maximum resolution and efficiency are the main objectives in the development of a capillary electrophoretic method for
the determination of solutes. In this paper we describe a specific, sensitive and robust method, using capillary zone
electrophoresis with internal standard and UV detection, for the separation and quantification of the anti-arrhythmic drug
mexiletine, its main phase I metabolites, and its main nitrogenous degradation product.
Keywords: Anti-arrhythmics, capillary zone electrophoresis, metabolites, mexiletine.
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