Recent studies suggest that dietary virgin olive oil reduces hypoxia-reoxygenation injury in rat brain. This
study investigated the effect of pretreatment with different doses of dietary virgin olive oil on brain lipidomics during
stroke. In this experimental trial, 60 male Wistar rats were studied in 5 groups of 12 each. The control group received
distilled water while three treatment groups received oral virgin olive oil for 30 days (0.25, 0.5 and 0.75 ml/kg/day
respectively). Also the sham group received distilled water. Two hours after the last dose, the animals divided two groups.
The middle cerebral artery occlusion (MCAO) group subjected to 60 min of middle cerebral artery occlusion (MCAO)
and intact groups for brain lipids analysis. The brain phosphatidylcholine, cholesterol ester and cholesterol levels
increased significantly in doses of 0.5 and 0.75 ml/kg/day compare with control group. VOO in all three doses increased
the brain triglyceride levels. VOO with dose 0.75 ml/kg increased the brain cerebroside levels when compared with
control group. VOO pretreatment for 30 days decreased the brain ceramide levels in doses of 0.5 and 0.75 ml/kg/day
(p<0.05). Although further studies are needed, the results indicate that the VOO pretreatment improved the injury of
ischemia and reperfusion and might be beneficial in patients with these disorders and seems to partly exert their effects via
change in brain lipid levels in rat.
Keywords: Brain lipids level, virgin olive oil, cholesterol, ceramide, neuroprotection, infarct volume.
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