Synthesis of Unnatural Amino Acids via Microwave-assisted Regio-selective One-pot multi-component Reactions of Sulfamidates

Author(s): Nasir B. R. Baig, Rajender S. Varma.

Journal Name: Current Organic Chemistry

Volume 17 , Issue 20 , 2013

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Synthesis of triazole based unnatural amino acids, triazole bis-amino acids and β-amino triazole has been described via stereo and regio-selective one-pot multi-component reaction of sulfamidates, sodium azide, and alkynes under MW irradiation conditions. The developed method is applicable to a broad substrate scope and has significant potential for the synthesis of triazole modified unnatural amino acids.

Keywords: Sulfamidates, Click chemistry, Unnatural amino acids, Triazole, Microwave.

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Article Details

Year: 2013
Page: [2323 - 2331]
Pages: 9
DOI: 10.2174/13852728113179990047
Price: $58

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