Current Hypertension Reviews

Prof. Kazuomi Kario
Jichi Medical University
School of Medicine


Diagnosis and Treatment of Unilateral Forms of Primary Aldosteronism

Author(s): Andrea Viola, Davide Tizzani, Silvia Monticone, Valentina Crudo, Maddalena Galmozzi, Jacopo Burrello, Karine Versace, Maria Loiacono, Franco Veglio, Paolo Mulatero.


Primary aldosteronism (PA) is now recognized as the most frequent form of secondary arterial hypertension. The importance of a correct and prompt diagnosis of PA is determined by its relevant prevalence, its increased cardiovascular risk compared to essential hypertension and by the possibility of reversing this increased risk with a targeted therapy. Surgical treatment of unilateral forms of PA (mainly aldosterone-producing adenomas) is at present recommended in well-selected patients because of its cost-effectiveness. Therefore, subtype differentiation of PA forms is of fundamental importance, and available guidelines recommend contrast-enhanced CT-scanning and adrenal venous sampling (AVS) as the main diagnostic tests for this purpose. In this review, we discuss the value of adrenal non-invasive imaging and AVS, the recent advances in complementary tests and, finally, the available data on the outcome of surgical treatment for PA.

Keywords: Adrenal vein sampling, aldosterone, aldosterone-producing adenoma, familial hyperaldosteronism, endocrine hypertension, primary aldosteronism.

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Article Details

Year: 2013
Page: [156 - 165]
Pages: 10
DOI: 10.2174/15734021113099990008
Price: $58