Therapeutic Approach for Neuronal Disease by Regulating Reninangiotensin System
Kousei Ohshima, Masaki Mogi and Masatsugu Horiuchi
Affiliation: Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Shitsukawa, Tohon, Ehime 791-0295, Japan.
The renin-angiotensin system (RAS) has been postulated to regulate not only systemic hemodynamic and
hydromineral homeostasis but also individualorgan function in the normal condition. On the other hand, its systemic and
localactivationleads to hypertension and diabetes mellitus,resulting intarget end organ damage.RAS in the brain is also
well known to be involved in the pathogenesis and progression of neuronal disease, as well as regulating blood pressure,
sympathetic activity, vasopressin secretion, thirst and sodium appetite.There is increasing evidence that RAS may
contribute to neuroinflammation associated with many neuronal diseases in several animal models. Moreover, recent
clinical evidence indicates that RAS blockade, including that byangiotensin converting enzyme inhibitors and angiotensin
II receptor blockers, has beneficial effects in treating stroke, cognitive dysfunction, Alzheimer disease and other neuronal
diseases, suggesting the potential of RAS as a new therapeutic target in neuronal diseases. This article reviews the recent
findings ofbrain RAS involvement and thetherapeutic potential of regulating RAS in neuronal disease.
Keywords: Angiotensin II, Neuroinflammation, Life-style related disorder, Stroke, Alzheimer disease, Parkinson disease,
Multiple sclerosis, Muscular dystrophy.
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