Recently, mass spectrometric related techniques have been widely applied for the identification and
quantification of neurochemicals and their metabolites in biofluids. This article presents an overview of mass
spectrometric techniques applied in the detection of neurological substances and their metabolites from biological
samples. In addition, the advances of chromatographic methods (LC, GC and CE) coupled with mass spectrometric
techniques for analysis of neurochemicals in pharmaceutical and biological samples are also discussed.
Keywords: Neurochemicals, LC-MS, GC-MS, CE-MS, MALDI-MS.
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