Current Organic Synthesis

Eduardo A. Castro
Universidad Nacional de La Plata
Buenos Aires
Argentina

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Synthesis of a Novel Class of gem-Phosphonate-Phosphates by Reductive Cleavage of the Isoxazolidine Ring

Author(s): Olga Bortolini, Iqbal Mulani, Antonio De Nino, Loredana Maiuolo, Alessandro Melicchio, Beatrice Russo and Donatella Granchi

Affiliation: Dipartimento di Chimica e Tecnologie Chimiche, Via P. Bucci, cubo 12C, Universita della Calabria, Rende (Italy).

Keywords: Apolipoprotein E, bisphosphonates, gem-phosphonate-phosphate rearrangement, isoxazolidines, ring opening, transition-metal carbonyls.

Graphical Abstract:


Abstract:

A new series of gem-phosphonate-phosphates bearing N-alkyl groups and aromatic substituents has been prepared by reductive cleavage of the isoxazolidine ring with metal carbonyls, using the gem-phosphonate-phosphate rearrangement.

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Article Details

VOLUME: 11
ISSUE: 3
Page: [461 - 465]
Pages: 5
DOI: 10.2174/15701794113109990061