The solubility of drugs is one of the most challenging aspects in developing formulations for novel drug discovery.
Myriad of approaches have been developed and tested to overcome the associated intricacies involved with poor
water soluble drugs. Out of the available technologies, solid dispersion (SD) method that significantly enhances the solubility
and bioavailability by reducing particle size to a micro-molecular level is often viewed as a promising strategy. Although
conceptual basis of manufacturing processes involved in SD method have been reported, formulation characteristics
addressing solubility issues remains yet elusive. The current review portray the historical milestones, classification,
probable mechanisms for enhancement of solubility, manufacturing processes at commercial level along with pioneer
breakthroughs in field that enunciates the versatile pharmaceutical application for categories including anti-cancer and
anti-retroviral drugs. Besides, our article also highlights the translational implications of drug development by SD method
Keywords: Drug development, Molecular targeting, Nanomedicine, Pharmaceutical biotechnology, Solid dispersion.
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