1,3,4-Oxadiazole Derivatives as Potential Biological Agents

Author(s): Juan Sun, Jigar A. Makawana, Hai-Liang Zhu.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 12 , 2013

Become EABM
Become Reviewer

Abstract:

The synthesis of novel compound libraries along with screening is a rapid and effective approach for the discovery of potential chemical agents, and it becomes an important method in pharmaceutical chemistry research. 1,3,4- oxadiazole derivatives as the typical heterocyclic compounds, exhibit a broad spectrum of biological activities and vital leading compounds for the development of chemical drugs. Herein, we focus on the synthesis and screening of novel 1,3,4-oxadiazoles derivatives with antimicrobial, antitumor or antiviral activities during the past decade. In this review, we discussed the synthetic development of 1,3,4-oxadiazoles derivatives, and also the relevant bioactivity and their prospects as the potential chemical drugs.

Keywords: 1, 3, 4-oxadiazole, synthesis, antimicrobial, anticancer, antiviral, bioactivities.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 13
ISSUE: 12
Year: 2013
Page: [1725 - 1743]
Pages: 19
DOI: 10.2174/13895575113139990071
Price: $58

Article Metrics

PDF: 21