Synthesis and In Vitro Evaluation of Some Hydrazone Derivatives as Potential Antibacterial Agents
Zafer Asim Kaplancikli,
Mehlika Dilek Altintop,
Nineteen N'-(benzylidene)-2-[(pyrimidin-2-yl)thio]acetohydrazides were obtained via the nucleophilic addition-
elimination reaction of 2-[(pyrimidin-2-yl)thio)]acetohydrazide with aromatic aldehydes. The synthesized compounds
were tested in vitro against various bacteria by microdilution. Among these compounds, N'-(3-
hydroxybenzylidene)-2-[(pyrimidin-2-yl)thio]acetohydrazide (3l) was found to be the most potent derivative (MIC 7.8-
15.62 µg/mL) against Staphylococcus aureus (ATCC 6538), Staphylococcus epidermidis (ATCC 12228), and Escherichia
coli (O157:H7-Clinical isolate), respectively. This outcome confirms that m-hydroxyphenyl moiety may have a considerable
influence on antibacterial activity of the series tested. In the view of the results of the current work, further research
can be carried out on the development of new effective antibacterial agents by the modification of compound 3l.
Keywords: Hydrazone, Pyrimidine, Antibacterial activity.
Rights & PermissionsPrintExport