Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and In Vitro Evaluation of Some Hydrazone Derivatives as Potential Antibacterial Agents

Author(s): Zafer Asim Kaplancikli, Mehlika Dilek Altintop, Ahmet Ozdemir, Gulhan Turan-Zitouni, Gamze Goger, Fatih Demirci.


Nineteen N'-(benzylidene)-2-[(pyrimidin-2-yl)thio]acetohydrazides were obtained via the nucleophilic addition- elimination reaction of 2-[(pyrimidin-2-yl)thio)]acetohydrazide with aromatic aldehydes. The synthesized compounds were tested in vitro against various bacteria by microdilution. Among these compounds, N'-(3- hydroxybenzylidene)-2-[(pyrimidin-2-yl)thio]acetohydrazide (3l) was found to be the most potent derivative (MIC 7.8- 15.62 µg/mL) against Staphylococcus aureus (ATCC 6538), Staphylococcus epidermidis (ATCC 12228), and Escherichia coli (O157:H7-Clinical isolate), respectively. This outcome confirms that m-hydroxyphenyl moiety may have a considerable influence on antibacterial activity of the series tested. In the view of the results of the current work, further research can be carried out on the development of new effective antibacterial agents by the modification of compound 3l.

Keywords: Hydrazone, Pyrimidine, Antibacterial activity.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Year: 2014
Page: [355 - 362]
Pages: 8
DOI: 10.2174/15701808113109990030
Price: $58