Exploring the Molecular Mechanism of Action Between Drug and RNA Polymerase Based on Partially-Resolved Spatial Structures
The RNA polymerase of Influenza A virus (IAV), which is comprised of three units PA, PB1 and PB2, is
involved in transcription and replication of the influenza virus. In order to develop effective treatment for IAV,
researchers have focused on designing drugs targeting IAV polymerase. Currently, crystal structures of the IAV
polymerase PA-PB1, PB1-PB2 complexes and the PA subunit have been obtained by several groups, providing useful
information regarding potential binding sites in drug design. However, to gain full understanding of the molecular
mechanism of IAV polymerase in viral transcription and replication, thereby aiding drug development, a complete
atomistic structure of the RNA polymerase is required. In this paper, we employed computer-aided drug design tools to
describe the complete structure of the RNA polymerase and proposed a putative mechanism. We predict that the
combination of Vancomycin and Oseltamivir will be an effective drug to universally treat IAVs with no resultant drug
resistance if this putative mechanism is true.
Keywords: Combination of drug and drug, drug resistance, non covalent bonds, target pocket, universal drug.
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