Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and Biological Evaluation of Arylthiourea Derivatives with Antitubercular Activity

Author(s): Rusong Luo, Tuomo Laitinen, Liyan Teng, Tapio Nevalainen, Maija Lahtela-Kakkonen, Baofu Zheng, Honghai Wang, Antti Poso, Xuelian Zhang.


Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis (M. tuberculosis), and remains one of the most life-threatening plagues for public health in the world. The emergence of drug resistant strains of TB and co-infection with HIV has further complicated TB treatment. Here, the synthesis and characterizaton of a series of compounds were described, and these were followed by evaluating for their antibacterial activity against M. tuberculosis. Several novel arylthiourea derivatives exhibited excellent activity (lowest MIC=0.09 μg/ml) against M. tuberculosis including drug resistant strains of M. tuberculosis. The results suggest that these compounds are promising candidates for new anti-TB agent development.

Keywords: Mycobacterium tuberculosis, Antitubercular agent, Arylthiourea, Synthesis, MIC.

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Article Details

Year: 2013
Page: [640 - 650]
Pages: 11
DOI: 10.2174/1570180811310070012
Price: $58