Synthesis and Biological Evaluation of Arylthiourea Derivatives with Antitubercular Activity
Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis (M. tuberculosis), and remains
one of the most life-threatening plagues for public health in the world. The emergence of drug resistant strains of
TB and co-infection with HIV has further complicated TB treatment. Here, the synthesis and characterizaton of a series of
compounds were described, and these were followed by evaluating for their antibacterial activity against M. tuberculosis.
Several novel arylthiourea derivatives exhibited excellent activity (lowest MIC=0.09 μg/ml) against M. tuberculosis including
drug resistant strains of M. tuberculosis. The results suggest that these compounds are promising candidates for
new anti-TB agent development.
Keywords: Mycobacterium tuberculosis, Antitubercular agent, Arylthiourea, Synthesis, MIC.
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