Synthesis and Antimicrobial Screening of Novel 3, 5-Disubstituted Indazole Derivatives

Title:Synthesis and Antimicrobial Screening of Novel 3, 5-Disubstituted Indazole Derivatives

Volume: 10 Issue: 7

Author(s): P. Padmaja, M. Yedukondalu, R. Sridhar, Siddhardha Busi and M. V. Basaveswara Rao

Affiliation:

Keywords: Amines, Acid and amine coupling, Antimicrobial activity, Antifungal activity, Indazole derivatives, Suzuki coupling.

Abstract: Amine coupling strategy was developed for the synthesis of new indazole derivatives through reaction of 4-(3- (4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl) benzoic acid 19 with amines 20a-i. All the newly synthesized compounds were screened for their antimicrobial and antifungal activities. Among the several compounds synthesized (4-(3-(4-hydroxyphenyl)-1H-indol-5-yl)phenyl)(piperazin-1-yl)methanone 2, (4-(3-(4-hydroxyphenyl)-1Hindazol- 5-yl)phenyl)(4-methylpiperazin-1-yl)methanone 3, 1-(4-(4-(3-(4-hydroxyphenyl)-1H-indol-5-yl) benzoyl) piperazin- 1-yl) ethanone 4 and (4-(3-(4-hydroxyphenyl)-1H-indol-5-yl) phenyl)(pyrrolidin-1-yl)methanone 9 showed potential activities against a variety of bacterial and fungal strains.

Cite this article as:

Padmaja P., Yedukondalu M., Sridhar R., Busi Siddhardha and Rao V. Basaveswara M., Synthesis and Antimicrobial Screening of Novel 3, 5-Disubstituted Indazole Derivatives, Letters in Drug Design & Discovery 2013; 10 (7) . https://dx.doi.org/10.2174/1570180811310070010