Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis of Novel Hydrazone Derivatives of 2, 5-difluorobenzoic Acid as Potential Antibacterial Agents

Author(s): Rajasekhar Narisetty, K. B. Chandrasekhar, Sandeep Mohanty, B. Balram.

Abstract:

Hydrazones are important classes of compounds found in many synthetic products. Due to their importance in synthetic chemistry, the present article reports the synthesis of twelve new hydrazone derivatives based on the coupling of 2,5-difluorobenzohydrazide with different benzaldehydes and screened for their antibacterial activities at the concentration 250 µg/mL with reference to the standard antibacterial drug Ampicillin. The screening results revealed that hydrazone derivatives 4d, 4e, 4f and 4h having fluorine substitution showed significant antibacterial activity comparable to that of standard drug Ampicillin.

Keywords: 2, 5-Difluoro benzoic acid, Aldehydes, Hydrazones, Antibacterial Activity, Fluorine, Gram positive.

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Article Details

VOLUME: 10
ISSUE: 7
Year: 2013
Page: [620 - 624]
Pages: 5
DOI: 10.2174/1570180811310070009
Price: $58