Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Antioxidant Activity of Thio-Schiff Bases

Author(s): Juliana Alves dos Santos, Rebeca Mol Lima, Thamiris Vilela Pereira, Antonio Marcio Resende do Carmo, Nadia Rezende Barbosa Raposo, Adilson David da Silva.

Abstract:

This study evaluated and compares the antioxidant activity of six resveratrol analogues. The analogues 4’- Hydroxyphenyl-benzo[d]thiazole (A), p-(N,N-dimethyl)aminobenzylidene-2-aminothiophenol (B) and p-Nitrobenzylidene- 2-aminothiophenol (C) were synthesized and the antioxidant activity was evaluated using the DPPH method. A descriptive statistical analysis and ANOVA followed by the Tukey test, with the aid of software. The best antioxidant activity was demonstrated by compound C (half maximal inhibitory concentration (IC50) = 18.45µM), this compound is two times more active than resveratrol (IC50= 37.28µM). Taken together, the data presented herein suggest that these molecules might serve as potential antioxidant considering that molecular modification is an effective strategy. As such, the compounds described herein can serve as prototypes for further research and the development of novel antioxidant agents.

Keywords: Antioxidants, Chemical synthesis, Resveratrol, Statistical analysis, Structure-activity relationship, Thio-Schiff bases.

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Article Details

VOLUME: 10
ISSUE: 7
Year: 2013
Page: [557 - 560]
Pages: 4
DOI: 10.2174/1570180811310070002
Price: $58