MicroRNAs in Cardiovascular Therapeutics

Author(s): Gerasimos Siasos, Dimitris Tousoulis, Panagiotis Tourikis, Savas Mazaris, Giorgos Zakynthinos, Evangelos Oikonomou, Eleni Kokkou, Christina Kollia, Christodoulos Stefanadis.

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 13 , 2013

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Abstract:

Recent research reveals the crucial role microRNAs (miRNAs) in the pathogenesis and progression of many pathological conditions, including cardiovascular diseases. It is widely documented that miRNAs represent critical regulators of cardiovascular function and participate in almost all aspects of cardiovascular biology. In particular, they are involved in several pathophysiological pathways of various manifestations of cardiovascular disease, such as coronary artery disease, heart failure, stroke, diabetes mellitus, arterial hypertension and cardiac arrhythmias. In the present article we review the available literature regarding to the role of miRNAs in certain cardiovascular conditions. Moreover, we discuss the therapeutic potential of miRNAs for treating cardiovascular diseases and we attempt to highlight future directions.

Keywords: microRNAs, cardiovascular disease, therapy, atherosclerosis.

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Article Details

VOLUME: 13
ISSUE: 13
Year: 2013
Page: [1605 - 1618]
Pages: 14
DOI: 10.2174/15680266113139990109
Price: $58

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