MicroRNAs in Peripheral Artery Disease

Author(s): Toshio Imanishi, Takashi Akasaka.

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 13 , 2013

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Abstract:

Peripheral arterial disease (PAD) is due to diffuse atherosclerosis. The pathological process is characterized mainly by the aberrant proliferation of vascular smooth muscle cells and the formation of neointimal lesions. MicroRNAs (miRNAs) are highly conserved non-coding small RNA molecules that regulate a large fraction of the genome by binding to complementary mRNA sequences, resulting in post-transcriptional gene silencing. Recent evidence has demonstrated that specific miRNAs are involved in the pathological development of PAD. In this review, the roles of specific miRNAs in PAD are summarized.

Keywords: MicroRNAs, peripheral arterial disease, angiogenesis.

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Article Details

VOLUME: 13
ISSUE: 13
Year: 2013
Page: [1589 - 1595]
Pages: 7
DOI: 10.2174/15680266113139990107
Price: $58

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