Diagnostic and Therapeutic Potentials of microRNAs in Heart Failure

Author(s): Evangelos Oikonomou, Gerasimos Siasos, Dimitris Tousoulis, Eleni Kokkou, Vasiliki Genimata, Konstantinos Zisimos, George Latsios, Christodoulos Stefanadis.

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 13 , 2013

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Abstract:

MicroRNAs are a class of evolutionarily small non-coding RNAs of 19 to 25 nucleotides in length, that represent one of the most exciting areas of current medical science as they can regulate a complex regulatory network of gene expression and physiologic processes including differentiation, proliferation and apoptosis in a highly context dependent fashion. Recently, their role in cardiovascular disease and in the regulation of cardiomyocyte size and function, in the action potential, in angiogenesis and in mitochondrial function was recognized. Importantly, they have been evaluated for their prognostic and diagnostic role in heart failure and modification of specific microRNAs levels has been tested as a therapeutic option in experimental heart failure models. In this review article we refer the most emerging evidence, concerning the role of microRNAs in myocardial development in heart failure pathophysiology and prognosis, and their therapeutic implications.

Keywords: Biomarkers, heart failure, microRNA, myocardial hypertrophy, prognosis, treatment.

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Article Details

VOLUME: 13
ISSUE: 13
Year: 2013
Page: [1548 - 1558]
Pages: 11
DOI: 10.2174/15680266113139990104
Price: $58

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