MicroRNAs: Biomarkers for Cardiovascular Disease in Patients with Diabetes Mellitus

Author(s): Alexandros Briasoulis, Dimitris Tousoulis, Georgia Vogiatzi, Gerasimos Siasos, Nikos Papageorgiou, Evangelos Oikonomou, Vasiliki Genimata, Theodosia Konsola, Christodoulos Stefanadis.

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 13 , 2013

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Abstract:

Diabetes mellitus (DM) is a complex metabolic disorder characterized by low insulin production/secretion by pancreatic beta cells and/or low responsiveness by insulin target tissues MicroRNAs have been associated with DM, but it is not clear whether this is a cause or an effect of metabolic abnormalities related to DM. In the hyperglycemic environment miRNAs are in involved in multiple stages of cardiovascular disease development and progression. In diabetic patients with cardiovascular disease miRNAs could potentially serve as early biomarkers for diagnosis and as therapeutic agents. The current review focuses on the involvement of miRNAs in molecular mechanisms underlying the pathogenesis of DM and its cardiovascular complications.

Keywords: miRNAS, diabetes mellitus, cardiovascular disease.

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Article Details

VOLUME: 13
ISSUE: 13
Year: 2013
Page: [1533 - 1539]
Pages: 7
DOI: 10.2174/15680266113139990102
Price: $58

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