Endothelial dysfunction reflected by reduced nitric oxide availability is nowadays considered as a causative
factor of atherosclerosis. A variety of biomarkers has been used as indicators of endothelial dysfunction in cardiovascular
disease. Discovered just over a decade ago, microRNAs have evoked a great deal of interest, due to their importance for
many aspects of homeostasis and disease. miRNAs comprise a novel class of endogenous, single-stranded, short RNA sequences
able to regulate gene expression by binding to complementary sequences on mRNAs According to a growing
body of evidence, they have been implicated in the regulation of several human physiological processes. They have been
shown to participate in cardiovascular disease pathogenesis including atherosclerosis and endothelial dysfunction and this
may have important clinical implications.
Keywords: Biomarkers, endothelial dysfunction, inflammation, mediators, microRNAs.
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