A Novel Three-Component Reaction for the Synthesis of 1,3-Benzoxazines in Water

Author(s): Faramarz Rostami-Charati.

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 16 , Issue 10 , 2013

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Abstract:

A simple and proficient method for the synthesis of 1,3-benzoxazine derivatives via three-component reaction of isocyanide and isoquinoline with 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone or 4-hydroxycumarine in water in the presence of piperidine at 70°C is reported.

Keywords: 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, 1, 3-benzoxazine, Isocyanide, isoquinoline, threecomponent reaction.

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Article Details

VOLUME: 16
ISSUE: 10
Year: 2013
Page: [840 - 844]
Pages: 5
DOI: 10.2174/1386207311301010009
Price: $58

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