Evaluation of Role of Oxidative Stress on Aging in Caenorhabditis elegans: A Brief Review
Kedar N. Prasad and Stephen C. Bondy
Affiliation: Antioxidant Research Institute, Premier Micronutrient Corporation, 14 Galli Drive, Suite 200, Novato CA 94949, USA.
Keywords: Antioxidants, aging, Caenorhabditis elegans, lifespan, oxidative stress, superoxide.
Recently the relationship between oxidative stress and aging has been brought into question. It has been suggested
that while oxidative events may play a role in the progression of age-related pathologies, it is not relevant to aging
processes not involving specific diseases associated with senescence. The evidence in support of this concept is largely
based on studies with the roundworm, Caenorhabditis elegans (C. elegans) that has been extensively used as a model system
to study aging. This commentary evaluates data derived from C. elegans and documents that the preponderance of
evidence from this species supports the role of pro-oxidant events as being a significant contributor to normal aging. Possible
reasons for some anomalous findings conflicting with this concept, are discussed.
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