Lappaconitine: Influence of Halogen Substituent on the Antiarrhythmic Activity
A. O. Bryzgalov,
V. E. Romanov,
T. G. Tolstikova,
E. E. Shults.
The current paper presents research results related to antiarrhythmic activity of halogen-containing derivatives
of lappaconitine. Lappaconitine derivatives with iodine, chlorine or bromine substituting the anthranilate moiety at C-5`
position were shown in vivo and in vitro to exhibit a more (Br, I) or less (Cl) pronounced antiarrhythmic activity in the
models of calcium chloride- and adrenaline-induced arrhythmias as compared with the reference compound lappaconitine.
The intensity of antiarrhythmic action depending on halogen substituent was found to be expressed by the following
order: Cl < I < Br.
Keywords: Arrhythmia, lappaconitine, halogen-containing lappaconitine derivatives.
Rights & PermissionsPrintExport