(S)-5-prolylamide-triazole Organocatalyst for Direct Asymmetric Aldol Reactions

Author(s): Ling Liu, Min-Na Gao, Yang Li, Zhen Li, Liping Song, Zhong-Wen Liu, Dong Xue, Zhao-Tie Liu.

Journal Name: Current Organic Chemistry

Volume 17 , Issue 14 , 2013

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Abstract:

A new proline derivative of (S)-5-prolylamide-triazole was synthesized and evaluated as an organocatalyst for the direct asymmetric aldol reaction of acetone with aromatic aldehydes under no extra solvent. At room temperature and in the absence of extra solvent, 15 mol% catalyst efficiently catalyzed the direct asymmetric aldol reactions to give aldol adducts, with modest enantiomeric excess (ee) of up to 74%. The titled reactions can be carried out in an environmentally friendly manner of no extra solvent and less catalyst loading.

Keywords: Asymmetric aldol reaction, Enantiomeric excess (ee) value, Organocatalyst, Proline derivative, (S)-5-prolylamide-triazole.

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Article Details

VOLUME: 17
ISSUE: 14
Year: 2013
Page: [1563 - 1568]
Pages: 6
DOI: 10.2174/1385272811317140011
Price: $58

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