Mechanisms of Catalysis in Confined Spaces: Hydrogenation of Norbornadiene with a Rhodium Complex included in a Self-Folding Cavitand

Author(s): Alex Hamilton, Michael Gicquel, Pablo Ballester, Carles Bo.

Journal Name: Current Organic Chemistry

Volume 17 , Issue 14 , 2013

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Abstract:

The reaction mechanism for the hydrogenation of norbornadiene (nbd) catalysed by bis-norbornadiene rhodium(I) [Rh(nbd)2]+ complex has been studied by means of DFT based methods, in the absence and in the presence of a self-folding octaamide cavitand. Formation of three products, norbornene, nortricyclene and a dimer is discussed. When the metal complex is encapsulated inside the cavitand, the steric crowding prevents formation of the dimer, while in the absence of the cavity, the dimer is the major product. Although energy differences between the studied reaction pathways are small, the present study explains the changes in regioselectivity when the hydrogenation reaction is carried out in a confined space.

Keywords: Cavitands, Supramolecular, Catalysis, Rhodium, Hydrogenation, DFT.

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Article Details

VOLUME: 17
ISSUE: 14
Year: 2013
Page: [1499 - 1506]
Pages: 8
DOI: 10.2174/1385272811317140006
Price: $58

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