Gating in Host-Guest Chemistry

Author(s): Fang Liu, Hao Wang, Kendall N. Houk.

Journal Name: Current Organic Chemistry

Volume 17 , Issue 14 , 2013

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Abstract:

Gating in host-guest chemistry refers to conformational changes that occur in response to some stimulus, resulting in opening or closing of a physical barrier that controls access to the host. Gating due to conformational changes of protein loops is common in enzyme catalysts: the binding of a substrate in an enzyme often involves the closing of a protein loop to bind the substrate, a type of gating [1]. Cram’s pioneering work in host-guest chemistry led to the discovery of one molecule inside another and the concept of container molecules. Cram’s nanometer-scaled container molecules were found by our group to involve gating to allow passage of guest molecules into or out of the container host [2]. The gating process in container molecules provides a novel way that binding and release of guest molecules can be controlled, and this has potential applications in controlled drug delivery.

Keywords: Gating, Host-guest chemistry.

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Article Details

VOLUME: 17
ISSUE: 14
Year: 2013
Page: [1470 - 1480]
Pages: 11
DOI: 10.2174/1385272811317140003

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