Chiral Separation of Propranolol Enantiomers by Oxidized Multiwalled Carbon Nanotubes/β-cyclodextrin Impregnated Thin-layer Chromatography
Xiao-Qing Chen, Cong-Hao Sun, Fei-Peng Jiao, Jin-Gang Yu and Xin-Yu Jiang
Affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.
Keywords: Enantioseparation, propranolol, β-cyclodextrin, oxidized multi-walled carbon nanotubes, thin-layer chromatography.
Extremely good enantioseparation of a kind of commonly used β-blockers, (±)-propranolol, has been achieved
on silica gel layers which were impregnated with β-cyclodextrin and oxidized multi-walled carbon nanotubes. Solvent
system tert-butenol-acetonitrile (1:1, v/v) successfully resolved the enantiomers of (±)-propranolol. The spots were detected
at 254 nm with a UV lamp. The effect of concentration of the mobile phase variation was also studied.
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