Therapeutic Strategies Targeting Glioblastoma Stem Cells

Author(s): Estefania Carrasco-Garcia, Nicolas Sampron, Paula Aldaz, Olatz Arrizabalaga, Jorge Villanua, Cristina Barrena, Irune Ruiz, Mariano Arrazola, Charles Lawrie, Ander Matheu.

Journal Name: Recent Patents on Anti-Cancer Drug Discovery

Volume 8 , Issue 3 , 2013

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Glioblastoma is the most common, aggressive and lethal brain tumor in adults. However, current therapeutic protocols have low success rates and average overall survival is less than 15 months. The resistance to therapy is largely a result of the remarkable cellular and phenotypical heterogeneity that characterizes this type of tumor. The discovery of a subpopulation of cells exhibiting stem cell properties within the tumor bulk has profound implications for therapy as increasing evidence indicates that these cells, glioblastoma stem cells (GSCs), are responsible for the origin, maintenance and recurrence of the glioblastomas. These findings highlight the need to characterize GSCs in order to find novel treatments directly targeted specifically against them. In this review, we summarize the current knowledge regarding this issue, including some recent and relevant patents.

Keywords: Glioblastoma, glioblastoma stem cells, molecular target, therapy.

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Article Details

Year: 2013
Page: [216 - 227]
Pages: 12
DOI: 10.2174/15748928113089990002
Price: $58

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