Chemistry and pharmacological activity of various types of Mannich bases and their derivatives were well documented. A survey
of the literature revealed extensive studies on the synthesis and reactivity of Mannich bases derived from ketones, amides, enamines,
phenols and indoles of widely different structures, while comparatively little attention has been given to Mannich bases derived from nitroalkanes
and related nitrocompounds. Mannich reactions using nitroalkanes and related compounds as substrates are of synthetic relevance
and the products are promising as biologically active substances. It is known that the nitro group is an important constituent of
many biologically significant heterocycles such as antibiotic drugs (nitrofurantoin and nitrofurazone). A number of nitro-heterocycles of
pharmacological interest were also synthesized by Mannich reactions with suitable nitro-substrates. In view of this, and because of the
widespread and increasing interest in the chemistry of Mannich bases, the present work is concerned with attempts to extend the scope of
Mannich reactions with nitroalkanes to include the synthesis of a variety of nitro N- and S-heterocycles.
Keywords: Asymmetric catalysis, Aza-Henry reaction, Nitroalkane, nitro-Mannich reaction, Reduction reaction, Vicinal diamines.
Rights & PermissionsPrintExport