According to the Green Chemistry principles, water is the first choice solvent to reduce chemical waste and environmental
impact of chemical industry. Reaction in water can be improved when microwave irradiation is applied to a synthetic procedure due to
the possibility to reach temperatures higher than the boiling point. This is especially true when reactions are carried out in superheated/
subcritical conditions (over 100 °C). In this paper, several synthetic procedures that use superheated or subcritical water as solvent
in sealed vials under microwave irradiation as heating system, are reviewed. Noteworthy, the targets of these synthesis are valuable compounds
of pharmaceutical interest.
Keywords: Green chemistry, Microwave, Subcritical, Superheated water.
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