Targeting Migrating Cells in Glioblastoma
Pp. 410-443 (34)
Ranjith Babu, Chunhui Di, Austin K. Mattox, Steve Harward and Cory Adamson
Glioblastoma multiforme (GBM) is the most common and aggressive
primary brain tumor in humans. Despite aggressive surgical resection using state-of-theart
neuroimaging and radiochemotherapy, the prognosis of GBM remains poor, with an
estimated median survival of 12-14 months. At presentation, tumor cells have already
have migrated into normal brain tissue beyond the main tumor mass. This accounts for
the inability of surgery to cure this tumor. It is therefore imperative to better understand
how inhibit GBM cell migration. In this review, we describe various potential targets
that may be exploited to inhibit the migration GBM cells.
Glioblastoma, migration, signaling, stem cell.
Neurosurgery Section, Durham VA Medical Center, DUMC Box 2624, Durham, NC 27710, USA