Advances in Anticancer Agents in Medicinal Chemistry

Volume: 2

Indexed in: EBSCO, Ulrich's Periodicals Directory

Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in ...
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Tripentones: A Promising Series of Potent Anti-Cancer Agents

Pp. 313-343 (31)

Christophe Rochais, Sylvain Rault and Patrick Dallemagne

Abstract

The 8H-thieno[2,3-b]pyrrolizinones, some of which exert very potent cytotoxic activity against tumor cell lines in vitro, are a promising novel series of anticancer agents. These compounds belong to the tripentone family and are based on 9Hpyrrolo[ 1,2-a]indol-9-one derivatives and their heterocyclic isosteres. This paper inventories the different synthetic strategies for tripentones and reviews their biological effects and therapeutic potential.

Keywords:

Tripentone, pyrrolizinone, pyrroloindolone, thiophene, cancer, pyrrole , heterocycles, clauson-kaas, acylation, ring closure.

Affiliation:

Université de Caen Basse-Normandie, CERMN EA 4258 – FR CNRS 3038 INC3M – SF 4206 ICORE, Bd Becquerel 14032 Caen cedex, France