Synthesis, Reactions and Biological Evaluation of 3-Amino-6- (subs.)thieno[2,3-b]pyridine-2-carbohydrazides

Author(s): Fawzy. A. Attaby, Ahmed H. El-Ghandour, Abdelwahed R. Sayed, Ashraf A. El Bassuony, Ahmed A. M. El-Reedy.

Journal Name:Current Bioactive Compounds

Volume 9 , Issue 2 , 2013

Abstract:

A new and efficient method for the preparation of 3-amino-6-thieno[2,3-b]pyridine-2-carbohydrazides and pyrido[3',2':4,5]thieno[3,2-d]pyramidinones from one-pot synthesis has been accomplished using 3-amino-6-thieno[2,3- b]pyridines with hydrazine hydrate in ethanol under reflux. This new protocol has the advantages of easy availability and high to excellent yields, simple experimental and work-up procedure. The synthesized compounds were confirmed through spectral characterization using IR, 1H NMR, mass spectra and elemental analyses.

Keywords: Thienopyridines, pyridinethiones pyridothienopyrimidinones, thienopyridineoxadiazoles, pyrazolothienopyridinone.

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2013
Page: [167 - 181]
Pages: 15
DOI: 10.2174/15734072113099990011
Price: $58