Synthesis, Reactions and Biological Evaluation of 3-Amino-6- (subs.)thieno[2,3-b]pyridine-2-carbohydrazides
Fawzy. A. Attaby, Ahmed H. El-Ghandour, Abdelwahed R. Sayed, Ashraf A. El Bassuony and Ahmed A. M. El-Reedy
Affiliation: Cairo University, Faculty of Science, Chemistry Department.
Keywords: Thienopyridines, pyridinethiones pyridothienopyrimidinones, thienopyridineoxadiazoles, pyrazolothienopyridinone.
A new and efficient method for the preparation of 3-amino-6-thieno[2,3-b]pyridine-2-carbohydrazides and
pyrido[3',2':4,5]thieno[3,2-d]pyramidinones from one-pot synthesis has been accomplished using 3-amino-6-thieno[2,3-
b]pyridines with hydrazine hydrate in ethanol under reflux. This new protocol has the advantages of easy availability and
high to excellent yields, simple experimental and work-up procedure. The synthesized compounds were confirmed
through spectral characterization using IR, 1H NMR, mass spectra and elemental analyses.
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