Current Bioactive Compounds

Adriano Mollica
Department of Pharmacy, University ”G. d' Annunzio” of Chieti-Pescara
Via dei Vestini 31
Chieti, 66100


Synthesis, Reactions and Biological Evaluation of 3-Amino-6- (subs.)thieno[2,3-b]pyridine-2-carbohydrazides

Author(s): Fawzy. A. Attaby, Ahmed H. El-Ghandour, Abdelwahed R. Sayed, Ashraf A. El Bassuony and Ahmed A. M. El-Reedy

Affiliation: Cairo University, Faculty of Science, Chemistry Department.

Keywords: Thienopyridines, pyridinethiones pyridothienopyrimidinones, thienopyridineoxadiazoles, pyrazolothienopyridinone.


A new and efficient method for the preparation of 3-amino-6-thieno[2,3-b]pyridine-2-carbohydrazides and pyrido[3',2':4,5]thieno[3,2-d]pyramidinones from one-pot synthesis has been accomplished using 3-amino-6-thieno[2,3- b]pyridines with hydrazine hydrate in ethanol under reflux. This new protocol has the advantages of easy availability and high to excellent yields, simple experimental and work-up procedure. The synthesized compounds were confirmed through spectral characterization using IR, 1H NMR, mass spectra and elemental analyses.

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Article Details

Page: [167 - 181]
Pages: 15
DOI: 10.2174/15734072113099990011