A new series of 4,5-dihydro-2H-indazoles was synthesized and evaluated for anti-inflammatory activity using
formalin-induced paw edema and turpentine oil-induced granuloma pouch bioassays. In addition, the inhibitory activity of
cyclooxygenase, ulcerogenic effect, and acute toxicity (ALD50) values were also determined. Compounds 10, 13, 15, 16,
18 and 22 were proved to display distinctive anti-inflammatory profiles with a fast onset of action. They revealed super GI
safety profile and are well tolerated by the experimental animals with high safety margin (ALD50 > 300 mg / Kg). The
same active compounds exhibited moderate to powerful selectivity profile towards the inhibition of COX-2 enzyme.
Docking poses for the most active compounds separately in the active site of human COX-2 enzyme were also obtained.
Keywords: Indazole, Anti-inflammatory activity, Ulcerogenic effect, Acute toxicity, COX-2, Docking.
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