Synthesis, Characterization of (Z)-N-(1-(2-(2-amino-3-(dimethylamino) methyl)phenyl)-5-phenyl-1,3,4, oxadiazol-3(2H)-yl)ethanone Analogs as Potent Antimicrobial and Hydrogen Peroxide Scavenging Agents

Author(s): Manav Malhotra, Vikramdeep Monga, Rajiv Sharma, Kapendra Sahu, Gaurav Sharma, Jainendra Jain, Aakash Deep.

Journal Name: Medicinal Chemistry

Volume 9 , Issue 5 , 2013

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Abstract:

A series of (Z)-N-(1-(2-(2-amino-3-((dimethylamino) methyl) phenyl)-5-phenyl-1,3,4,oxadiazol-3(2H)- yl)ethanone derivatives was prepared and studied for its antimicrobial and antioxidant activities. Among the synthesized derivatives, compounds (7c) (Z)-N-(1-(2-(2-amino-3-((dimethylamino)methyl)phenyl)-5-phenyl-1,3,4-oxadiazol-3(2H)- yl)ethylidene)-4-chloroaniline, (7g) (Z)-N-(1-(2-(2-amino-3-((dimethylamino)methyl)phenyl)-5-phenyl-1,3,4-oxadiazol- 3(2H)-yl)ethylidene)-4-nitroaniline and (7i) (Z)-N-(1-(2-(2-amino-3-((dimethylamino)methyl)phenyl)-5-phenyl-1,3,4- oxadiazol-3(2H)-yl)ethylidene)-4-methoxyaniline were found to be the most effective antimicrobial compounds. While the compounds 7c and 7g were the most potent antioxidant compounds with significant hydrogen peroxide scavenging activity.

Keywords: Mannich Bases, Lipophilicity, 1, 3, 4-Oxadiazoles, Antimicrobial and antioxidant activities.

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Article Details

VOLUME: 9
ISSUE: 5
Year: 2013
Page: [710 - 717]
Pages: 8
DOI: 10.2174/1573406411309050011
Price: $58

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