Nerve agents such as sarin, VX and tabun are organophosphorus compounds able to inhibit an enzyme acetylcholinesterase
(AChE). AChE reactivators and anticholinergics are generally used as antidotes in the case of intoxication
with these agents. None from the known AChE reactivators is able to reactivate AChE inhibited by all kinds of nerve
agents. In this work, reactivation potency of seventeen structurally different AChE reactivators was tested in vitro and
subsequently, relationship between their chemical structure and biological activity was outlined. VX was chosen as appropriate
member of the nerve agent family.
Keywords: Nerve agent, VX, Reactivation, Acetylcholinesterase, Oxime.
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