A series of peptidomimetic containing bidentate pTyr mimetics (9a-w) are reported as potent and selective
PTP1B inhibitors. Compounds (9p and 9q) showed excellent selectivity towards PTP1B over various PTPs, including
TCPTP (in vitro), which confirms discovery of highly potent and selective PTP1B inhibitors.
Keywords: Tri-peptides, pTyr mimetics, PTP1B inhibitors, TCPTP, Type 2 diabetes, Metabolic disorders.
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