Peptidomimetics as Potent and Selective PTP1B Inhibitors

Author(s): Dipam Patel, Mukul Jain, Shailesh R. Shah, Rajesh Bahekar, Pradip Jadav, Kiran Shah, Amit Joharapurkar, Mubeen Shaikh, Kalapatapu V.V.M. Sairam.

Journal Name: Medicinal Chemistry

Volume 9 , Issue 5 , 2013

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Abstract:

A series of peptidomimetic containing bidentate pTyr mimetics (9a-w) are reported as potent and selective PTP1B inhibitors. Compounds (9p and 9q) showed excellent selectivity towards PTP1B over various PTPs, including TCPTP (in vitro), which confirms discovery of highly potent and selective PTP1B inhibitors.

Keywords: Tri-peptides, pTyr mimetics, PTP1B inhibitors, TCPTP, Type 2 diabetes, Metabolic disorders.

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Article Details

VOLUME: 9
ISSUE: 5
Year: 2013
Page: [660 - 671]
Pages: 12
DOI: 10.2174/1573406411309050005
Price: $58

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