Elevated blood pressure or hypertension is one of the fastest growing health problems worldwide. Although the
etiology of essential hypertension has a genetic component, dietary factors play an important role. With the high costs and
adverse side-effects associated with synthetic antihypertensive drugs and the awareness of the link between diet and health
there has been increased focus on identification of food components that may contribute to cardiovascular health. In recent
years special interest has been paid to the cardioprotective activity of peptides derived from food proteins including marine
proteins. These peptides are latent within the sequence of the parent protein and only become active when released by
proteolytic digestion during gastrointestinal digestion or through food processing. Current data on antihypertensive activity
of marine-derived protein hydrolysates/peptides in animal and human studies is reviewed herein. Furthermore, products
containing protein hydrolysates/peptides from marine origin with antihypertensive effects are discussed.
Keywords: ACE inhibitory, antihypertensive, bioactive peptides, human studies, marine organisms, SHR.
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