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Current Vascular Pharmacology
ISSN (Print): 1570-1611
ISSN (Online): 1875-6212
Epub Full Text Article
DOI: 10.2174/15701611113119990129      Price:  $95









Role, function and therapeutic potential of microRNAs in vascular aging

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Author(s): Felix Jansen, Xiaoyan Yang, Georg Nickenig, Nikos Werner and Mariuca Vasa- Nicotera
Abstract:
Due to increased life expectancy in a growing world population, the impact of ageing on the pathophysiology of cardiovascular diseases will increase. Therefore, a better understanding of age-related biological changes is important and necessary to combat cardiovascular diseases in the future.

microRNAs (miRs) a small non coding RNAs emerging as key regulator in several vascular pathologies such as atherosclerosis or hypertension, which show a clear association with increasing age. This review discusses the involvement of miRs in several age-associated pathologies such as oxidative stress, vascular inflammation, vascular tension, endothelial cell senescence and impaired angiogenesis.

Keywords:
microRNA, vascular, ageing
Affiliation:
Mariuca Vasa-Nicotera Medizinische Klinik und Poliklinik II Universitätsklinikum Bonn 53105 Bonn, Germany