Title:Proresolution Mediators and Receptors: Novel Drug Targets for Enhancing Pharmacological Armamentarium against Periodontal Inflammation
VOLUME: 13 ISSUE: 1
Author(s):Vishakha Grover, Ranjan Malhotra, Anoop Kapoor, Jasvinder Singh and Sonia Sachdeva
Affiliation:Baba Farid University of Health Sciences, India.
Keywords:Drug targets, Inflammation, Lipid mediator, Lipoxin, Resolution, Resolvin.
Abstract:Periodontal diseases are comprised of a group of inflammatory conditions that result in the destruction of the
supporting structures of the dentition. Emphasis has traditionally been placed on the deleterious actions of lipid mediators,
such as prostanoids and leukotrienes, in propagating the inflammatory response and enhancing tissue destruction. Recently,
the emerging understanding of the molecular basis of inflammation has elucidated that return of tissue homeostasis,
triggered as part of a normal inflammatory response i.e. resolution of inflammation is an active, agonist-mediated,
well-orchestrated phenomenon. The naturally-occurring pro-resolution lipid mediators, lipoxins, resolvins, protectins,
maresins etc. have been identified as a novel genus of potent and stereoselective players that counter-regulate excessive
acute inflammation and stimulate molecular and cellular events that define resolution. In this Review, we provide an update
and overview of newly identified mediators that play pivotal roles in resolution and focus on the emerging appreciation
of the endogenous pathways and mediators that control timely resolution which can be exploited as novel drug targets
to extend the pharamaceutical armamentarium to combat chronic inflammation, thus controlling periodontal inflammation
and the associated systemic inflammatory effects on the body, in general.
