Progress Review on Kinesin Spindle Protein Inhibitors as Anti- Cancer Agents
Pp. 240-268 (29)
Yingjie Zhang and Wenfang Xu
The kinesin spindle protein (KSP, also known as Hs Eg5) plays an essential
role in the proper separation of spindle poles and the correct formation of bipolar
mitotic spindle during mitosis. Inhibition of this protein results in cells apoptosis
followed by mitotic arrest and the formation of characteristic monoaster spindles.
Compared with the traditional chemotherapeutic agents (taxanes, vinca alkaloids), KSP
inhibitors (KSPi) will not lead to the neuropathic side effects, so KSP has become a
novel and an attractive anticancer target. Accordingly, more and more interest has been
focused on the development of high effective and selective KSPi. This review will focus
on some kinds of KSPi on the basis of introducing structure and function of KSP.
Kinesin, KSP, uncompetitive inhibitor, competitive inhibitor,
Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Ji’nan, Shandong, China