Bipolar, epilepsy and migraine disorders are frequently reported as co-morbid conditions. In this review article
we highlight some of the similarities between these disorders, exploring at various levels including cellular, structural and
phenotypic changes. Clinical observations suggest considerable overlap with a number of common neurobiological
features. Nonetheless, the courses of development of each disorder remain to be elucidated such that there is much room
for further research into their precise underlying mechanisms. A better understanding of the neurobiology of these
disorders will help to improve current treatments, particularly when there is co-morbidity and presence of treatment
resistant and complex cases.
Keywords: Bipolar disorder, comorbidity, depressive disorders, epilepsy, migraine, psychopharmacology.
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