Abstract
Chiral sulfoxides are extensively used in synthesis of chiral drugs, total synthesis of natural products and organic synthesis. Among them, chiral sulfoxide drugs in market or under research mostly have nitrogen-containing substructures. In common titanium catalysts have better catalytic property in asymmetric oxidation of these nitrogencontaining sulfide precursors than other catalysts. The ligands of these titanium catalysts have tartarate, BINOL and other diols, salens and others. Proton pump inhibitors, anti-inflammatory drugs, anti-cancer drugs, antibiotics, platelet adhesion inhibitors, antipsychotic drugs, lipid regulators, potassium channel openers, neurokinin inhibitors and so on are valuable chiral sulfoxide drugs. The research advances of synthesis of various chiral sulfoxide drugs catalyzed by titanium are described in this review.
Keywords: Titanium catalyst, asymmetric catalysis, sulfide oxidation; chiral sulfoxides, chiral drugs.
Mini-Reviews in Organic Chemistry
Title:Advances in Titanium-Catalyzed Synthesis of Chiral Sulfoxide Drugs
Volume: 10 Issue: 2
Author(s): Qingle Zeng, Shan Gao and Allan Kipruto Chelashaw
Affiliation:
Keywords: Titanium catalyst, asymmetric catalysis, sulfide oxidation; chiral sulfoxides, chiral drugs.
Abstract: Chiral sulfoxides are extensively used in synthesis of chiral drugs, total synthesis of natural products and organic synthesis. Among them, chiral sulfoxide drugs in market or under research mostly have nitrogen-containing substructures. In common titanium catalysts have better catalytic property in asymmetric oxidation of these nitrogencontaining sulfide precursors than other catalysts. The ligands of these titanium catalysts have tartarate, BINOL and other diols, salens and others. Proton pump inhibitors, anti-inflammatory drugs, anti-cancer drugs, antibiotics, platelet adhesion inhibitors, antipsychotic drugs, lipid regulators, potassium channel openers, neurokinin inhibitors and so on are valuable chiral sulfoxide drugs. The research advances of synthesis of various chiral sulfoxide drugs catalyzed by titanium are described in this review.
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Cite this article as:
Zeng Qingle, Gao Shan and Chelashaw Kipruto Allan, Advances in Titanium-Catalyzed Synthesis of Chiral Sulfoxide Drugs, Mini-Reviews in Organic Chemistry 2013; 10 (2) . https://dx.doi.org/10.2174/1570193X11310020008
DOI https://dx.doi.org/10.2174/1570193X11310020008 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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