Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated
from numerous genera of sponges (Agela sp, Raspailia sp). Nuttingins and malonganenones are tetraprenylated
purine alkaloids from gordonian (Eplexura sp, Leptogorgia sp). Some of these alkaloids displayed broad spectrum activity
including cytotoxic activity against several cancer cells. The review summarizes the synthesis of mono- or bi-cyclic diterpenoids
usually having a 9-methyladenine moiety.
Keywords: Alkyl purine, terpene purine, agelasine, ageline, ageloxime, gelasine, agelasimine, asmarine, nuttingin, malonganenone.
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