CD4+ T-cells are central players orchestrating antigen-specific immunity and tolerance. Importantly, dendritic
cells (DCs) are responsible for priming T-cells and for promoting their differentiation from naïve T-cells into appropriate
functional cells. Because of their fundamental roles in controlling immunity, activation and differentiation of DCs and
CD4+ T-cells require tight regulatory mechanisms. Several studies have shown that dopamine, not only mediates
interactions into the nervous system, but it can also contribute to the modulation of immunity. Here, we review the
emerging role of this neurotransmitter as a regulator of DCs and CD4+ T-cells physiology and its consequent involvement,
in the regulation of immune response. We specially focus the analysis in the role of dopamine receptor D5 expressed on
DCs and CD4+ T-cells in the modulation of immunity. We also discuss how alterations in the dopamine-mediated
regulation of immunity could contribute to the onset and development of immune-related disorders.
Keywords: CD4+ helper T-cells, dendritic cells, dopamine, regulatory T-cells, T-cell mediated immunity.
Rights & PermissionsPrintExport