Stem Cell Regenerative Potential Combined with Nanotechnology and Tissue Engineering for Myocardial Regeneration
The stem cell-based therapy for post-infarction myocardial regeneration has been introduced more than a decade
ago, but the functional improvement obtained is limited due to the poor retention and short survival rate of transplanted
cells into the damaged myocardium. More recently, the emerging nanotechnology concepts for advanced diagnostics
and therapy provide promising opportunities of using stem cells for myocardial regeneration. In this paper will be
provided an overview of the use of nanotechnology approaches in stem cell research for: 1) cell labeling to track the distribution
of stem cells after transplantation, 2) nanoparticle-mediated gene delivery to stem cells to promote their homing,
engraftment, survival and differentiation in the ischemic myocardium and 3) obtaining of bio-inspired materials to provide
suitable myocardial scaffolds for delivery of stem cells or stem cell-derived factors.
Keywords: Cell transplantation, myocardial infarction, myocardial regeneration, nanoparticles, nanotechnology, stem cells.
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